That aside, this is a great, accurate documentary of heavy metal. He's drunk out of his mind and makes it quite clear that he hates life, is an alcoholic, had a heavily dysfunctional childhood and will be dead soon. The only depressing footage is an interview with Chris Holmes of WASP. Interesting to see Ozzy Osbourne years before that reality show he did for MTV. The interviews with fans of the music are just as fun. The bands come across as very upbeat and accessible. The whole feeling of the film is actually uplifting and very funny. ![]() The movie makes no judgments on the performers or their music.they leave that up to the audience. The contrasts and their views on music, drugs and sex are very interesting and illuminating. There are just fascinating talks with old time performers (Alice Cooper, Aerosmith, Ozzy Osbourne) and newcomers (Odin, WASP, Poison). The second in Penelope Spheeris’ trilogy, The Metal Years takes a fast-paced look at the outrageous Heavy Metal scene of the late '80s. Unlike the first "Decline." this movie concentrates more on interviews than concert footage. 'It's a wickedly straight-on peek into the Rock 'n' Roll subculture of Heavy Metal.' Michael Wilmington, Los Angeles Times IT'S MORE THAN MUSIC. Decline III was also released separately via streaming video.Great documentary of the heavy metal scene of the late 1980s. According to an article by Laura Snapes, "there was little demand to see such a depressing movie, and the few distribution offers that Spheeris got required her to hand over the rights to the first two movies, which she refused to do". This was partly due to Spheeris refusing to relinquish the rights to the first two parts of the trilogy in order to enable the third to be released. However, it never went into general release and was not available on VHS or DVD until the release in 2015 of a box set containing all three films on DVD and Blu-ray. It was screened at the Cannes Film Festival and the Chicago Underground Film Festival, where it received a jury award. The film premiered at the 1998 Sundance Film Festival where it won the Freedom of Expression Award. County Jail awaiting trial for his murder. The film ends by listing the fate of two of the interviewees in "Squid", who having died on Jfrom multiple stab wounds along with "Spoon" being in L.A. Performances by four bands were filmed: Final Conflict, Litmus Green, Naked Aggression, and The Resistance. Musicians interviewed include Keith Morris ( Black Flag, Circle Jerks), Rick Wilder ( The Mau-Mau's), and Flea ( Fear, Red Hot Chili Peppers) Morris had previously appeared in the first The Decline of Western Civilization. Near the end, the film shows a memorial squat location near where a local squatter in Stephen Chambers had died in a fire. Los Angeles Police Department officer Gary Fredo and a paralyzed youth living on disability benefits are also interviewed. Spheeris talks to homeless teenagers living on the street or squatting in abandoned buildings in Los Angeles that go by the names of "Why-Me?", "Hamburger", "Troll", "Eyeball", "Squid", and others. The film involves gutter punks who take the anti-establishment message with extreme seriousness and tune out society completely. It is dedicated to "Squid, Stephen Chambers, and all the gutterpunks that survive." Synopsis Īs mentioned in the opening credits, the film shot between July 1996 and August 1997 in Los Angeles. She began a relationship with a man she met while filming the movie, signed up to be a foster parent, and eventually fostered five children. ![]() Spheeris later credited the 1998 film with having a profound effect on her. ![]() The second film, The Decline of Western Civilization Part II: The Metal Years (1988), covers the Los Angeles heavy metal movement of 1986–1988. The first film, The Decline of Western Civilization (1981), dealt with the punk rock scene during 1980–1981. It is the third film of a trilogy by Spheeris depicting life in Los Angeles at various points in time. The Decline of Western Civilization III is a 1998 documentary film, directed by Penelope Spheeris, that chronicles the gutter punk lifestyle of homeless teenagers.
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![]() Keene was incorporated as a city in 1874, and by 1880 had a population of 6,784. Keene became a manufacturing center for wooden-ware, pails, chairs, sashes, shutters, doors, pottery, glass, soap, woolen textiles, shoes, saddles, mowing machines, carriages and sleighs. After the railroad was constructed to the town in 1848, numerous other industries were established. The Ashuelot River was later used to provide water power for sawmills, gristmills and tanneries. Timothy Dwight, the Yale president who chronicled his travels, described the town as ".one of the prettiest in New England." Situated on an ancient lake bed surrounded by hills, the valley with fertile meadows was excellent for farming. Land was set off for the towns of Sullivan and Roxbury, although Keene would annex 154 acres (0.62 km 2) from Swanzey (formerly Lower Ashuelot).īoston and Maine railroad yard in Keene, c. Located at the center of Cheshire County, Keene was designated as the county seat in 1769. : 96 It was regranted to its inhabitants in 1753 by Governor Benning Wentworth, who renamed it "Keene" after Sir Benjamin Keene, English minister to Spain and a West Indies trader. : 79 Colonists fled to safety, but would return to rebuild in 1749. In 1747, during King George's War, the village was attacked and burned by Natives. When the boundary between the Massachusetts Bay and New Hampshire colonies was fixed in 1741, Upper Ashuelot became part of New Hampshire, although Massachusetts continued supporting the area for its own protection. : 21–22 Settled after 1736 on Equivalent Lands, it was intended to be a fort town protecting the Province of Massachusetts Bay from the French and their Native allies during the French and Indian Wars, the North American front of the Seven Years' War. In 1735, colonial Governor Jonathan Belcher granted lots in the township of "Upper Ashuelot" to 63 settlers who paid £5 each. The grocery wholesaler C&S Wholesale Grocers is based in Keene. ![]() It hosted the state's annual pumpkin festival from 1991 to 2014, several times setting a world record for most jack-o'-lanterns on display. ![]() Keene is home to Keene State College and Antioch University New England. The population was 23,047 at the 2020 census, down from 23,409 at the 2010 census. Keene is a city in, and the seat of Cheshire County, New Hampshire, United States. ![]() Midazolam injection should not be administered by rapid injection in the neonatal population as severe hypotension and seizures have been reported. The initial dose and all subsequent doses should always be titrated slowly. Use only in settings that can provide for continuous monitoring of respiratory and cardiac function. In the event of an opioid overdose, emergency personnel can use a drug called naloxone to reverse the life-threatening effects of opioids.Midazolam has been associated with respiratory depression and respiratory arrest, especially when used for sedation in noncritical care settings. There’s no treatment specifically for pinpoint pupils because it’s not a disease. How is drug-induced pinpoint pupils treated?Īny of the listed drugs and those that belong in their drug class can cause pinpoint pupils, especially during an overdose. Either alone or in combination, studies have shown that this drug can cause pinpoint pupils. But hydrocodone is also implicated in the causation of pinpoint pupils. Typically, it is dispensed as the combinations acetaminophen/hydrocodone or ibuprofen/hydrocodone, for pain severe enough to require an opioid and in combination with homatropine methylbromide to relieve cough. Hydrocodone: Hydrocodone is an opioid used to treat pain and as a cough suppressant. However, oxycodone can also cause your pupils not to respond to changes in lighting, especially at high doses. ![]() Oxycodone: Oxycodone is a potent opioid that can be useful when used judiciously for pain. Studies reveal that morphine acts on a subcortical region causing constriction of the pupil. However, morphine is listed as one of the drugs that cause pinpoint pupils. Morphine is also used preoperatively to reduce anxiety, cause sedation and reduce the dose of anesthetic. Morphine is a very efficacious drug for the relief of moderate to severe pain and is the standard by which all other agents are measured. Morphine: Morphine is one of several important alkaloids derived from the poppy plant, Papaver somniferum. Fentanyl constricts the pupils and causes pinpoint pupils which do not respond to changes in light. Studies reveal that people taking methadone show smaller pupil diameters.įentanyl: Fentanyl, also spelled fentanil, is a powerful opioid used as a pain medication and, together with other medications, for anesthesia. ![]() However, the drug can also cause pinpoint pupils. Methadone helps individuals achieve and sustain recovery and to reclaim active and meaningful lives. When taken as prescribed, methadone is safe and effective. Methadone: Methadone is a medication approved by the Food and Drug Administration (FDA) to treat opioid use disorder (OUD) as a medication-assisted treatment (MAT), as well as for pain management. Studies reveal that following the administration of codeine, pupil size can decrease significantly as plasma concentrations of codeine increase. Codeine is an Opiate and a Narcotic that can also cause pinpoint pupils. ![]() Tylenol 3, a popular Painkiller, is Codeine combined with Acetaminophen. It comes in tablet form and is the main ingredient in prescription-grade cough suppressants. When heroin is injected into a vein, it produces a surge of euphoria, or “rush.” The effects include detachment from physical and emotional pain, pinpoint pupils, itchiness, and sweating.Ĭodeine: This is a prescription pain medication used to treat mild to moderate pain. Heroin: An opioid drug made from morphine, a natural substance taken from the seed pod of the various opium poppy plants grown in Southeast and Southwest Asia, Mexico, and Colombia. ![]() The PD structure lacks a potential endonuclease domain. However, in a further paper, an alternative explanation of the results was provided which made the authors doubt the existence of trimming endonuclease activity. Initially, it was suggested that Pol θ performs end trimming using the intrinsic endonuclease activity associated with the PD (repurposing of metal ions in the polymerase active site for endonucleolytic cleavage). Nonhomologous regions should be removed and the 3′-tails should be shortened before initiation of DNA synthesis from annealed microhomologies. ![]() The presence of nonhomologous segments flanking the microhomologies at the 3′-ends complicates TMEJ. The alternative clamp RAD9-RAD1-HUS1 complex (9-1-1), Fanconi anaemia group D2 protein (FANCD2) and 5-hydroxymethylcytosine-binding protein (NMCES) possibly also play a role in the recruitment of Pol θ to DNA ]. It was suggested that PARylation can promote the dissociation of Pol θ from DNA strands and termination of DNA synthesis in the end of TMEJ. However, PARP1-dependent PARylation of the Pol θ HD in vitro decreases the ssDNA-binding affinity of Pol θ. Chromosomal TMEJ assays revealed that PARP1/PARP2 deficiency reduces TMEJ activity only 2–4-fold through a decrease in the 5′-3′ resection of DSB, and, thus, re-channels repair to NHEJ. Competing with Ku proteins for DNA ends binding, PARP1 promotes a-EJ, and its inhibition impairs Pol θ recruitment to DNA break sites. PARP1 is activated upon binding DNA strand breaks and performs post-translational modification (PARylation) of many DNA repair proteins. TMEJ is also regulated by poly(ADP) ribose polymerase 1 (PARP1). melanogaster revealed that Pol θ is a critical factor of Lig4 (DNA ligase 4)-independent alternative end joining (a-EJ). Goff et al., demonstrated the sensitivity of POLQ-defective bone-marrow cells to γ-radiation and bleomycin, suggesting the role of Pol θ in DSB repair. About 90% of chaos1 homozygous mice with an ATM-deficient background died during the neonatal period and surviving animals exhibited severe growth retardation and chromosome instability which was synergistic to the ATM-deficiency phenotype. The analysis of Polq chaos 1/ Polq chaos 1 mice with an ATM (ataxia telangiectasia mutated) deficiency allowed the suggestion that Pol θ might be involved in an alternative DSB repair pathway distinctive from the major HR ATM-dependent pathway. The phenotype-based screening of mutant mice showed that the missense mutant allele chaos1 (a C>T substitution at nucleotide 5794 in the coding region of exon 19) of the Polq gene leads to a spontaneous and radioactivity-induced increase in micronuclei number in erythrocytes. It took more than a decade to uncover the molecular basis underlying the role of Pol θ in DSB repair. Īt present, the importance of Pol θ for DSB repair is well-established. The inactive exonuclease-like subdomain, lacking catalytic residues essential for metal-ion binding and primer degradation, has two conserved loops. These contacts can facilitate DNA lesions bypass and the extension of poorly annealed DNA termini during TMEJ. The thumb residues K2181 and R2202 as well as the Insert 2 R2254 residue make unique upstream contacts with the 3′-terminal primer phosphates (n-1–n-5). These elements play a crucial role in the TLS activity and the ability of Pol θ to use primers with only minimal homology to DNA templates during TMEJ. Insert 2 and Insert 3 are located in the palm subdomain and are comprised of 58 and 33 amino acids, respectively. Its proximity to DNA suggests a role in DNA binding. Insert 1 consists of 31 amino acid residues between the first and second conserved motifs and is located in the thumb subdomain. These insertion loops are not found in the two other A-family polymerases. Three conserved loop elements are located within the PD. Importantly, the HD forms a tetramer (a dimer of dimers) both in the crystals and in solution, providing the structural basis for the bridging and annealing of DNA strands by Pol θ. Purified HD is able to unwind different types of DNA with 3′-5′ polarity (in an ATP-dependent manner) and reanneal them. DNA-dependent ATPase activity in vitro is associated with the HD. melanogaster, Caenorhabditis elegans, and even archaea. The HD sequence similarity is observed among Homo sapiens, Mus musculus, D. Among them are the nucleotide-binding site and two RecA-like subdomains (residues 1–289 and 290–513) containing motifs I–VI, which are conserved across SF2 helicases. The HD is composed of five structural elements. The high-resolution cryo-EM structure of the PD of Lates calcarifer Pol θ is also available. Crystal structures of the separate SF2 HD and polymerase domain (PD) of human Pol θ have been solved. Unlike other DNA polymerases, Pol θ contains a separate superfamily 2 (SF2) helicase-like domain (HD) located on the N-terminus of the protein. ![]() ![]() In the meantime, please leave a comment or two to let us know what you think. One of the significant new features that the game had, was the use a first-person perspective instead of traditional side-scrolling action. The game was developed by the Nintendo-owned Retro Studios and published by Nintendo. We knew at the time that development was in the early stages as. We didn’t anticipate this change for a variety of reasons, but if it does, we’ll update the story accordingly. Metroid Prime is the first game in the series in 3D and the first Metroid game released in eight years after Super Metroid. One of Nintendos big surprises at E3 two years ago was the announcement of Metroid Prime 4. A return to the First Person Adventure gameplay focused on action, isolation, and exploration. Metroid Prime 4 New Topic Page of 30 Next Last Game Detail Platform: Nintendo Switch Genre: Action » Shooter » First-Person » Arcade Developer: Retro Studios Publisher: Nintendo Release: TBA. As you’d expect, this speculation was not commented on by Nintendo. Developed by a new team under Nintendo producer Kensuke Tanabe. It’s impossible to know what should and shouldn’t be done in this investigation, especially since it’s coming from Nintendo UK and not Nintendo. Add to that the stealthy release of Metroid Prime Remastered earlier this year, and some Nintendo fans can’t help but wonder if this year, or possibly next, is finally time for Metroid Premium 4 to come out.įor now, let’s take it all in here, speculation. Specifically, it noted that “ seems like a good way to pass the time until Metroid Prime 4 comes out.” It’s nothing remarkable in itself, but many Nintendo fans have pointed out that setting up Metroid Prime 4 isn’t just weird, it’s talk about releasing it if it doesn’t come out soon. Yes, Metroid Prime 4 is still in development, according to new job ad By Rhys Wood published 27 January 2022 Samus's first-person outing is still on the way (Image credit: Nintendo) Audio. You are currently watching Metroid Prime 4 Speculation shorts.Be in the loop on the latest video. Metroid Prime 4 returns to the first person adventure roots of the original Metroid prime game and introduces a new storyline that ties together the events of the Metroid Prime universe. The survey was sent out recently by Nintendo UK and specifically asked Nintendo fans a question regarding Metroid Prime Remastered, and in the process referred to Metroid Prime 4. Hello Community Welcome to the Gaming News channel. Enjoy playing the Jetpack Joyride Mod APK 1.69. With this mod, this Jetpack Joyride will be easy for you. In this mod, Unlimited money, everything unlocked. What you would expect in a Arcade is available in this. Jetpack Joyride Mod APK 1.69.1 (Unlimited money, everything unlocked) is the most famous version in the Jetpack Joyride Mod APK 1.69.1 (Unlimited money, everything unlocked) series of publisher Halfbrick Studios. You can disable this feature in the settings menu of your device. This game contains optional in-app purchases. ⚡Test your reflexes with simple one-touch controls ⚡Earn achievements and battle it out against friends ⚡Storm the lab in giant mechs and crazy vehicles ⚡Collect coins and make millions of dollars The character is controlled by tapping on the screen to activate the jetpack and move up, or releasing the screen to descend. ⚡Dodge lasers, zappers, and guided missiles Jetpack Joyride Mod Apk 1.75.1 (Everything Unlocked, No Ads, Mod Menu)game features simple and intuitive controls that make it easy for players to pick up and play. ⚡Customise your look with ridiculous outfits ⚡Complete daring missions to boost your rank Join over 750 million players and download Jetpack Joyride on the Google Play Store!ĭownload FREE now to start a new game and escape the lab! It's time to join Barry Steakfries and equip cool jetpacks, suit up in stylish costumes and ride crazy vehicles in his endless running quest to beat the scientists to the end of the lab. ![]() ![]() Bullet-powered jetpacks! Giant mechanical dragons! Birds that shoot money!įrom the makers of Fruit Ninja comes this insane, high flying endless runner that will keep you on the edge of your seat! ![]() No extra experience, no shiny amulet on my screen. (I’m also a little peeved that I got cheated out of the amulet for killing a 100,000 HP monster – it said I got it, but I didn’t. I’ve yet to manage any of the Challenge Amulets – I’m pretty sure you need the unlimited waves mode in Premium to get most of them. I mean, there’s a bunch of stuff I haven’t done yet, but I’m trying to think what kind of things could qualify as “stats” – i.e. ![]() (Can you ever see them in the non-Premium version? I’m almost at the fourth Crafting Pylon and haven’t seen one yet.) Can’t imagine what else there is. I assume one of them is “Shadows killed”, I haven’t encountered any of those yet. Number of times mana pool was extendedĥ5. Most mana spent on monster banishment in one battleĥ4. Total mana spent on monster banishmentĥ2. Monster nests destroyed with gem bombsĥ1. Monster nests destroyed with tower shotsĤ9. Highest amount of gems on scene at the same timeĢ7. Highest number of non-combined gem killsĢ0. Most mana spent on creating gems in one battleġ9. Total mana spent on creating/combining gemsġ8. Mana spent on creating mana gathering gemsġ7. Mana spent on creating multiple damage gemsġ6. Mana spent on creating bloodbound gemsġ5. Mana spent on creating armor tearing gemsġ4. This helps exploring the labyrinth and giving you some extra XP before trying the fields with tougher settings.Anyone have all the stats unlocked yet? I’ve got 61/64, and I’m wondering what’s missing.
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![]() By picking a theme for your sale (if you have one), selecting the right time to hold it, joining forces with your neighbors, advertising properly and making sure that your stuff works before buyers take it home, you will be well on your way to a successful indoor garage sale experience. In addition, if you are selling any battery-powered equipment, keep a fresh supply of batteries handy for your customers, so they can be assured that the equipment they are interested in actually operates properly.Īs you prepare to move and declutter your home, holding an indoor garage sale is a quick and easy way to put your unwanted items to good use. There is nothing more frustrating to a garage sale shopper than to arrive home and discover that the blender they just bought will not turn on. If your indoor garage sale includes any electric appliances, be sure to have a power cord available so buyers can test out your stuff. Have arrows and other easy-to-understand directions so people to find you. Keep the signs simple to read, so passing motorists can get the message quickly. Indoor garage sales with a very specific focus tend to draw more crowds than garden variety ones do.Įxperts say that indoor garage sale events should be heavily advertised, with at least 10-20 signs spread all throughout the local area. Should you find yourself with a lot of leftover baby clothes, feature that category in your advertising. If you find that you have a good deal of lawn equipment to sell, market your sale with a special landscaping theme. Indoor garage sales that feature a specific theme tend to attract peoples’ attention. In addition, by pooling your collective efforts, you can get the word out to more people about the dates of the sale and what items will be offered. Multifamily, indoor garage sales are very enticing to bargain shoppers, as there is more merchandise to search through at the same time. Talk to your neighbors to see if they want to participate along with you. Here are some great tips on how to hold a successful indoor garage sale, even during the colder months.Ĭheck with your local church, community center or school to see if they would be willing to allow you to utilize their building for an indoor garage sale in exchange for a small donation. No matter what time of the year it is, having an indoor garage sale is a great way to unload your extra stuff and also make a few bucks at the same time. It is the perfect time to part with belongings that you no longer want or need. Please also be aware that Klipsch warranties are non-transferable.Industry experts always say that the process of moving gives people the chance to declutter their lives. ![]() Repeat violators are subject to being banned.Ĭontinued abuse of this section will result in its discontinuation without notice. Any post violating the above guidelines will be subject to being closed and/or deleted, and the posting member warned.Post about other topics in their relevant sub-forums elsewhere on the Klipsch boards. Best Garage Sale PowerPoint Templates Presentation theme featuring increase in sales sky is the limit money income profit business Presentation design. Please keep topics ON-TOPIC, and avoid "thread-crapping". Do not post about thses issues on the forum. Reporting issues: If you feel someone has abused this section of the forum, you must report it directly to a Klipsch Admin or mod using the "report" button. You may post a link to your item on sites such as eBay, Audiogon, and Craigslist, however discussions/disagreements concerning these sites or any payment site (i.e., PayPal) are not permitted. Public discussions concerning transactions or disagreements are not permitted. No commercial advertising or sales solicitations by a business.Klipsch reserves the right to delete any post without warning. Remember to be diligent with any online transaction, verifying the legitimacy of the seller and item before purchasing. Klipsch is not responsible for verifying the authenticity of sales posted here. Klipsch is not involved with sellers or buyers from this section in any way, and cannot be held liable for any problems occurring with transactions. |
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