![]() Midazolam injection should not be administered by rapid injection in the neonatal population as severe hypotension and seizures have been reported. The initial dose and all subsequent doses should always be titrated slowly. Use only in settings that can provide for continuous monitoring of respiratory and cardiac function. In the event of an opioid overdose, emergency personnel can use a drug called naloxone to reverse the life-threatening effects of opioids.Midazolam has been associated with respiratory depression and respiratory arrest, especially when used for sedation in noncritical care settings. There’s no treatment specifically for pinpoint pupils because it’s not a disease. How is drug-induced pinpoint pupils treated?Īny of the listed drugs and those that belong in their drug class can cause pinpoint pupils, especially during an overdose. Either alone or in combination, studies have shown that this drug can cause pinpoint pupils. But hydrocodone is also implicated in the causation of pinpoint pupils. Typically, it is dispensed as the combinations acetaminophen/hydrocodone or ibuprofen/hydrocodone, for pain severe enough to require an opioid and in combination with homatropine methylbromide to relieve cough. Hydrocodone: Hydrocodone is an opioid used to treat pain and as a cough suppressant. However, oxycodone can also cause your pupils not to respond to changes in lighting, especially at high doses. ![]() Oxycodone: Oxycodone is a potent opioid that can be useful when used judiciously for pain. Studies reveal that morphine acts on a subcortical region causing constriction of the pupil. However, morphine is listed as one of the drugs that cause pinpoint pupils. Morphine is also used preoperatively to reduce anxiety, cause sedation and reduce the dose of anesthetic. Morphine is a very efficacious drug for the relief of moderate to severe pain and is the standard by which all other agents are measured. Morphine: Morphine is one of several important alkaloids derived from the poppy plant, Papaver somniferum. Fentanyl constricts the pupils and causes pinpoint pupils which do not respond to changes in light. Studies reveal that people taking methadone show smaller pupil diameters.įentanyl: Fentanyl, also spelled fentanil, is a powerful opioid used as a pain medication and, together with other medications, for anesthesia. ![]() However, the drug can also cause pinpoint pupils. Methadone helps individuals achieve and sustain recovery and to reclaim active and meaningful lives. When taken as prescribed, methadone is safe and effective. Methadone: Methadone is a medication approved by the Food and Drug Administration (FDA) to treat opioid use disorder (OUD) as a medication-assisted treatment (MAT), as well as for pain management. Studies reveal that following the administration of codeine, pupil size can decrease significantly as plasma concentrations of codeine increase. Codeine is an Opiate and a Narcotic that can also cause pinpoint pupils. ![]() Tylenol 3, a popular Painkiller, is Codeine combined with Acetaminophen. It comes in tablet form and is the main ingredient in prescription-grade cough suppressants. When heroin is injected into a vein, it produces a surge of euphoria, or “rush.” The effects include detachment from physical and emotional pain, pinpoint pupils, itchiness, and sweating.Ĭodeine: This is a prescription pain medication used to treat mild to moderate pain. Heroin: An opioid drug made from morphine, a natural substance taken from the seed pod of the various opium poppy plants grown in Southeast and Southwest Asia, Mexico, and Colombia.
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